Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2019, vol. 49, nr 2, July-December, p. 71–79

doi: 10.17219/pim/122016

Publication type: review article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Comprehensive review of the role of acrylic acid derivative polymers in floating drug delivery system

Beena Kumari1,2,A,B,C, Aparna Khansili2,B,D,E, Parmita Phougat3,B,D, Manish Kumar4,D,F

1 Department of Pharmaceutical Sciences, Indira Gandhi University, Rewari, India

2 Department of Pharmacy, School of Medical and Allied Sciences, GD Goenka University, Gurugram, India

3 Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India

4 MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, India

Abstract

In the development of drug delivery systems, an oral drug delivery system is the preferred route of drug administration. Many components play an important role in developing a drug delivery system. Amongst those components, polymers have evolved with these systems. Macromolecule compounds consisting of many monomer units which are joined to each other by different bonds are known as polymers. For drugs that are absorbed primarily in the upper gastrointestinal tract, floating drug delivery systems offer an additional advantage. The purpose behind this review was to focus on different types of floating drug delivery systems and different types of polymers used in floating drug delivery systems, focusing on acrylic acid derivatives and their applications. In this review, the main emphasis is on acrylic acid derivative polymers, their formulation and grades, and various patents on these types of polymers. Based on the literature survey, mainly 2 types of polymers are used in this drug delivery system; i.e., natural and synthetic. Examples of natural polymers are xanthan gum, guar gum or chitosan, and synthetic polymers include acrylic acid derivatives and hydroxylpropyl methylcellulose (HPMC). Eudragit and Carbopol are the most widely used acrylic acid derivatives.

Key words

acrylic polymers, Eudragit, floating drug delivery system, acrylic acid derivatives, carbomer

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