Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2020, vol. 50, nr 2, July-December, p. 75–78

doi: 10.17219/pim/131644

Publication type: review article

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Focus on COVID-19: Antiviral polymers in drugs and vaccines

Jakub Stojanowski1,A,B,C,D,E,F, Tomasz Gołębiowski2,B,C,D,E,F

1 Students’ Scientific Club, Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Poland

2 Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Poland

Abstract

Pathogenic viral factors pose a serious epidemiological threat and challenge to the world population, as proven by the scale and rapidity of COVID-19 pandemic outbreak. Polymer macromolecules can be an alternative to the accepted forms of treatment. Polymeric substances can be used as drugs or as adjuvants in vaccines. The most important feature of polymers is their advanced structure and the ability to construct the molecule from scratch, giving it the desired properties. Antiviral properties are influenced by, among other things, electrical charge, form and structure, and composition with other polymers or heavy metals. Depending on the expected properties, molecules can be built from scratch to be capable of transporting drugs or improve the effectiveness of the right drug. They can also be antiviral drugs in themselves. Polymeric compounds allow to reduce the frequency of adverse effects and improve the effect of the drug. They can have a direct antiviral effect by upsetting the lipid membrane of the surrounding viruses. Antiviral action of polymers occurs because of the properties of the polymers alone or in combination with other molecules. Viral epidemics are a motivation for research that can help stop a global pandemic in the future.

Key words

polymers, coronavirus, pandemics, antivirals, antiviral agents

References (14)

  1. Feng X, Li M, Li Y, Ding J. Smart and functional polymers. Molecules. 2019;24(16):2976. doi:10.3390/molecules24162976
  2. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733. doi:10.1056/NEJMoa2001017
  3. Schandock F, Riber CF, Röcker A, et al. Macromolecular antiviral agents against zika, ebola, SARS, and other pathogenic viruses. Adv Healthc Mater. 2017;6(23):1700748. doi:10.1002/adhm.201700748
  4. Kryger MB, Wohl BM, Smith AA, Zelikin AN. Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug. Chem Commun (Camb). 2013;49(26):2643–2645. doi:10.1039/c3cc00315a
  5. Milewska A, Kaminski K, Ciejka J, et al. HTCC: Broad range inhibitor of coronavirus entry. PLoS One. 2016;11(6):e0156552. doi:10.1371/journal.pone.0156552
  6. Ye S, Shao K, Li Z, et al. Antiviral activity of graphene oxide: How sharp edged structure and charge matter. ACS Appl Mater Interfaces. 2015;7(38):21571–21579. doi:10.1021/acsami.5b06876
  7. Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Rapid in-vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using povidone-iodine oral antiseptic rinse. J Prosthodont. 2020;29(6):529–533. doi:10.1111/jopr.13209
  8. Kariwa H, Fujii N, Takashima I. Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents. Der-matology. 2006;212(Suppl 1):119–123. doi:10.1159/000089211
  9. Hu CJ, Chang W, Fang Z, et al. Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus. Sci Rep. 7;1:13043. https://doi.org/10.1038/s41598-017-13316-0
  10. Honda-Okubo Y, Barnard D, Ong CH, Peng BH, Tseng CT, Petrovsky N. Severe acute respiratory syndrome-associated coronavirus vaccines formu-lated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology. J Virol. 2015;89(6):2995–3007. doi:10.1128/JVI.02980-14
  11. Koźbiał M, Gierycz P. Comparison of aqueous and 1-octanol solubility as well as liquid–liquid distribution of acyclovir derivatives and their complexes with hydroxypropyl-β-cyclodextrin. J Solution Chem. 2013;42(4):866–881. doi:10.1007/s10953-013-9995-8
  12. Garrido PF, Calvelo M, Blanco-González A, et al. The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2. Int J Pharm. 2020;588:119689. doi:10.1016/j.ijpharm.2020.119689
  13. Wang Y, Hu Y, He Q, et al. Metal-organic frameworks for virus detection. Biosens Bioelectron. 2020;169:112604. doi:10.1016/j.bios.2020.112604
  14. Lee JB, Roh YH, Um SH, et al. Multifunctional nanoarchitectures from DNA-based ABC monomers. Nat Nanotechnol. 2009;4(7):430–436. doi:10.1038/nnano.2009.93
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