Polymers in Medicine

Polim. Med.
Index Copernicus (ICV 2022) – 121.55
MEiN – 70
Average rejection rate – 39.13%
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2020, vol. 50, nr 1, January-June, p. 33–40

doi: 10.17219/pim/128473

Publication type: original article

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Evaluation of starch-clay composites as a pharmaceutical excipient in tramadol tablet formulations

Cecilia O. Alabi1,B,C,D, Inderbir Singh2,A,C,D, Oluwatoyin Adepeju Odeku1,A,C,D,E,F

1 Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Nigeria

2 Chitkara College of Pharmacy, Chitkara University, Patiala, India

Abstract

Background. Co-processing starch with clay nanocomposite has been shown to yield a new class of materials, potentially with better properties than pristine starch, that could be used as directly compressible excipients in tablet formulations.
Objectives. In this study, starches from 3 botanical sources, i.e., millet starch from Pennistum glaucum (L) RBr grains, sorghum starch from Sorghum bicolor L. Moench grains and cocoyam starch from Colocasia esculenta L. Schott tubers, were co-processed with montmorillonite clay (MMT) and evaluated as a directly compressible excipient in tramadol tablet formulations. The effects of different starch-to-clay ratios on the material and drug release properties of the resulting tablets were evaluated.
Material and Methods. The starch-clay composites were prepared by heating a dispersion of the starch in distilled water, then precipitating the dispersion with an equal volume of 95% ethanol. The starch-clay composites were characterized and used as direct compression excipients for the preparation of tramadol tablets. The mechanical and drug release properties of the tablets were evaluated.
Results. Co-processing MMT with the starches yielded starch-clay composites with different material and tablet properties than the pristine starches. The co-processed starch-MMT biocomposites exhibited improved flowability and compressibility over the pristine starches. The mechanical and drug release properties of tramadol tablets containing starch-clay composites were significantly better than those containing only pristine starches. The properties of the starch-clay composites were not related to the botanical source of the starches.
Conclusion. The study showed that starch-clay biocomposites could be used in the controlled release of tramadol.

Key words

starch, tablets, excipients, biocomposite, dissolution test

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