Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2018, vol. 48, nr 1, January-June, p. 25–29

doi: 10.17219/pim/99799

Publication type: review article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Porous starch and its application in drug delivery systems

Monika Sujka1,A,D, Urszula Pankiewicz1,C,F, Radosław Kowalski1,E, Karolina Nowosad1,B, Agnieszka Noszczyk-Nowak2,E,F

1 Department of Analysis and Evaluation of Food Quality, University of Life Sciences in Lublin, Poland

2 Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wrocław University of Environmental and Life Sciences, Poland

Abstract

In recent years, starch has become a new potential biomaterial for pharmaceutical applications. This biopolymer has unique physicochemical and functional characteristics, as well as various advantages such as low price, relative ease of isolation in pure form from the plant source, non-toxicity, biodegradability, good biocompatibility, and interaction with living cells. Starch is currently used in pharmacy as a binder, disintegrating agent, film-forming material, raw material for production of microspheres and nanoparticles, and a component of drug delivery systems. Porous starch, which can be obtained with physical, chemical and enzymatic methods of modification, has a large specific surface area thanks to the presence of pores and channels. It has excellent adsorption capacity and can be used to enhance the dissolution rate of poorly soluble drugs or as shell material to improve the stability and water-solubility of compounds. As a component of drug delivery systems, porous starch has another advantage: it is biodegradable, so there is no need to remove it from the body after the release of the active agent.

Key words

starch, porosity, drug delivery systems

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