Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2017, vol. 47, nr 2, July-December, p. 101–106

doi: 10.17219/pim/90020

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Formulation and evaluation of controlled-release matrix systems of ciprofloxacin

Venkata Ramana Malipeddi1,A,B,C,D,E,F, Rajendra Awasthi2,A,B,C,D,E,F, Kamal Dua3,A,B,C,D,E,F

1 Amity Institute of Pharmacy, Amity University, Lucknow, India

2 NKBR College of Pharmacy & Research Centre, Phaphunda, India

3 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Australia

Abstract

Background. Ciprofloxacin is a broad-spectrum fluoroquinolone antibacterial drug to which most Gram-negative and many Gram-positive bacteria are highly susceptible. Fluoroquinolones are administered repeatedly, twice a day for 5 days, during the course of therapy. Hence, they require repeated administration. Ciprofloxacin qualifies as a drug candidate for a controlled-release drug delivery system.
Objectives. The present work was aimed to develop ciprofloxacin hydrochloride-containing matrix tablets by the wet granulation method.
Material and Methods. The tablets were prepared using EthocelTM 100 Premium and Eudragit® RS PO (Evonik Laboratory, Mumbai, India) as a rate-controlling polymer. Granular dioctyl phthalate (DCP) was used as a diluent. An isopropyl alcohol and dichloromethane (1:1) mixture was used as a granulating agent. The effect of the formulation variables on tablet performance was examined based on weight variation, hardness, friability, thickness, and drug release profiles. The results suggested that the tablets had good integrity.
Results. The tablets were stable for 18 months. Formulation F7 gave a linear release pattern up to 12 h. The release of ciprofloxacin from formulation F7 followed zero-order kinetics. The release mechanism was found to be diffusion-controlled as the Higuchi equation was obeyed.
Conclusion. Ciprofloxacin hydrochloride-containing matrix tablets were prepared successfully. The tablets had good integrity and were found stable for 18 months.

Key words

ciprofloxacin hydrochloride, diffusion-controlled, EthocelTM 100 Premium, Eudragit® RS PO, matrix tablet

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