Polymers in Medicine

Polim. Med.
Index Copernicus (ICV 2022) – 121.55
MEiN – 70
Average rejection rate – 39.13%
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2017, vol. 47, nr 1, January-June, p. 5–11

doi: 10.17219/pim/70498

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Buccal patches of atenolol formulated using fenugreek (Trigonella foenum-graecum L.) seed mucilage

Surya Narayan Ratha Adhikari1,A,B,C,D,E, Satyabrata Panda1,C,E,F

1 Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Odisha, India

Abstract

Background. The use of mucoadhesive natural polymers in designing mucoadhesive patch systems has received much attention.
Objectives. The study involved the development and evaluation of buccal patches of atenolol using fenugreek (Trigonella foenum-graecum L.) seed mucilage with hydroxylpropyl methyl cellulose (HPMC K4M) and a backing membrane (ethyl cellulose 5% w/v).
Material and Methods. These atenolol-releasing buccal patches were prepared using a solvent casting technique. The buccal patches prepared were evaluated for average weight, thickness, drug content, folding endurance and moisture content. Ex vivo mucoadhesive strength, force of adhesion and bonding strength were determined using porcine buccal mucosa. The mucosal permeation of atenolol through the porcine buccal mucosa was carried out using a Franz diffusion cell in phosphate buffer saline, pH 6.8. These buccal patches were also characterized by SEM and FTIR spectroscopy.
Results. The average weight, thickness, drug content, folding endurance and moisture content of these atenolol-releasing buccal patches were found satisfactory for all the patches. Amongst all, the F-4 buccal patch showed maximum mucoadhesive strength (31.12 ±1.86 g), force of adhesion (30.53 × 10–2 N) and bond strength (1748.89 N/m2). Ex vivo atenolol permeation from the buccal patches showed drug permeation across the excised porcine buccal mucosa over 12 h. The F-4 buccal patch showed maximum permeation flux (29.12 μg/cm2/h).
Conclusion. The developed atenolol-releasing buccal patches can be beneficial over the conventional drug delivery systems to decrease the dosing frequency and enhance patient compliance.

Key words

fenugreek seed mucilage, HPMC, mucoadhesion, buccal patches, atenolol

References (25)

  1. Hao H, Heng PWS. Buccal drug delivery systems. Drug Dev Ind Pharm. 2003;29:821–832.
  2. Avachat AM, Gujar KN. Development and evaluation of tamarind seed xyloglucan-based mucoadhesive buccal films of rizatriptan benzoate. Carbohydr Polym. 2013;91:537–542.
  3. Koland M, Charyulu RN, Prabhu P. Mucoadhesive films of losartan potassium for buccal delivery: Design and characterization. Indian J Pharm Educ Res. 2010;44:315–323.
  4. Boylan JC. Drug delivery buccal route. In: J. Swarbrick (ed.), Encyclopedia of Pharmaceutical Technology. Suppl. 3, Marcel Dekker Inc 2001, 800–811.
  5. De Vries ME, Bodde HE, Verhoef JC, Junginger HE. Developments in buccal drug delivery. Crit Rev Ther Drug Carrier Syst. 1991;8:271–303.
  6. Shojaei AH. Buccal mucosa as a route for systemic drug delivery. Review. J Pharm Pharmaceut Sci. 1998;1:15–30.
  7. Smart JD. Buccal drug delivery. Exp Opin Drug Deliv. 2005;2:507–517.
  8. Shiledar RR, Tagalpallewar AA, Kokare CR. Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan. Carbohydr Polym. 2014;101:1234–1242.
  9. Verma N, Wahi AK, Verma A, Chattopadhayay P. Evaluation of mucoadhesive buccal patches for delivery of atenolol. J Pure Appl Microbiol. 2007;1:115–118.
  10. Patel VM, Prajapati BG, Patel MM. Design and characterization of chitosan- containing mucoadhesive buccal patches of propranolol hydrochloride. Act Pharm. 2007;57:61–72.
  11. Pongjanyakul T, Suksri H. Alginate-magnesium aluminum silicate films for buccal delivery of nicotine. Colloids Surf B Biointerf. 2009;74:103–113.
  12. Jug M, Bećirević-Laćan M, Bengez S. Novel cyclodextrin-based film formulation intended for buccal delivery of atenolol. Drug Dev Ind Pharm. 2009;35:796–807.
  13. Krishnarth N, Verma N, Sharma N. Formulation & evaluation of muccoadhesive buccal patches for delivery of atenolol. Int J Pharm. 2014;4:166-170.
  14. Ratha Adhikari SN, Nayak BS, Nayak AK, Mohanty B. Formulation and evaluation of buccal patches for delivery of atenolol. AAPS PharmSciTech. 2010;11:1038–1044.
  15. Satishbabu BK, Srinivasan BP. Preparation and evaluation of buccoadhesive films of atenolol. Indian J Pharm Sci. 2008;70:175–179.
  16. Nayak AK, Pal D, Pradhan J, Ghorai T. The potential of Trigonella foenum-graecum L. seed mucilage as suspending agent. Indian J Pharm Educ Res. 2012;46:312–317.
  17. Nayak AK, Pal D, Pradhan J, Hasnain MS. Fenugreek seed mucilage-alginate mucoadhesive beads of metformin HCl: Design, optimization and evaluation. Int J Biol Macromol. 2013;54:144–154.
  18. Nafee NA, Ahemed F, Borale A. Preparation and evaluation of mucoadhesive patches for delivery of cetylpyridinium chloride (CPC). Acta Pharm. 2003;2:199–212.
  19. Attama AA, Akpa PA, Onugwa LE, Igwilo G. Novel buccoadhesive delivery system of hydrochlorothiazide formulated with ethyl cellulose-hydroxypropyl methylcellulose interpolymer complex. Sci Res Essays. 2008;3:343-347.
  20. Gupta A, Garg S, Khar RK. Measurement of bioadhesion strength of muco-adhesive buccal tablet: Design of an in vitro assembly. Indian Drugs. 1992;30:152–155.
  21. Malakar J, Sen SO, Nayak AK, Sen KK. Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery. Saudi Pharm J. 2012;20:355–363.
  22. Malakar J, Sen SO, Nayak AK, Sen KK. Development and evaluation of microemulsions for transdermal delivery of insulin. ISRN Pharmaceutics. 2011 (2011) Article ID 780150.
  23. Park H, Robinson JR. Mechanism of bioadhesion of poly (acrylic acid) hydrogels. Pharm Res. 1987;4:457–464.
  24. Das B, Nayak AK, Nanda U. Topical gels of lidocaine HCl using cashew gum and Carbopol 940: Preparation and in vitro skin permeation. Int J Biol Macromol. 2013;62:514–517.
  25. Cozar O, Chis V, David L, Baias M. Experimental and density functional theory investigation of some biomedical compounds. J Optoelectronics Adv Mater. 2006;8:164–171.
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