Polymers in Medicine

Polim. Med.
Index Copernicus (ICV 2022) – 121.55
MEiN – 70
Average rejection rate – 39.13%
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

Download PDF

Polymers in Medicine

2017, vol. 47, nr 1, January-June, p. 25–33

doi: 10.17219/pim/76059

Publication type: original article

Language: English

Download citation:

  • BIBTEX (JabRef, Mendeley)
  • RIS (Papers, Reference Manager, RefWorks, Zotero)

Creative Commons BY-NC-ND 3.0 Open Access

Film forming properties of Cissus pulpunea (Guill and Perr) and Irvingia gabonensis (O’Rorke) gums

Tolulope Omolola Ajala1,B,C,D,E,F, Hope Idemudia Olaiya2,B,C,F, Oluwatoyin Adepeju Odeku2,A,C,E,F

1 Department of Pharmaceutics and Industrial University of Ibadan, Ibadan, Nigeria

2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria

Abstract

Background. Natural polymers such as gums have gained attention in drug delivery systems due to their availability, compatibility and degradation under natural and physiological conditions.
Objectives. The aim of the present study was to investigate the film forming properties of gums obtained from the stem of Cissus polpunea (Guill and Perr) and the seed of Irvingia gabonensis (O’Rorke).
Material and Methods. Gums were extracted from the relevant plant parts and characterized using functional, proximate and elemental properties. Films were prepared by the casting method using gum concentrations of 1–4% w/v and varied with propylene glycol (PG). The films were assessed through physical observation, thickness, swelling power and moisture sorption effects using the relative humidity of 0, 27, 43, 57, 75 and 90%. The gum yielding optimal film properties was used as coating material in ibuprofen tablet formulations. The mechanical and release properties of the tablets were determined.
Results. The functional and proximate properties of gums showed a similarity in the majority of the parameters, but significant (p < 0.05) variation existed in their solubility, while elemental assessment revealed the absence of toxic metals. Generally, the films were homogenous, opaque and demonstrated high swelling power in phosphate buffer, which was pH-dependent. Moisture sorption properties of the gums increased with the increase in relative humidity in the order HPMC < Cissus < Irvingia. Film-coated ibuprofen tablets showed higher mechanical properties and disintegration and dissolution times compared with uncoated tablets.
Conclusion. Cissus and irvingia gums have demonstrated acceptable functional, proximate and elemental properties. Film-coated ibuprofen tablets showed higher mechanical and release properties than was the case in uncoated tablets.

Key words

Cissus polpunea gum, Irvingia gabonensis gum, ibuprofen tablet, film and coating properties

References (27)

  1. Kulkarni AP, Shaikh YR, Dehghan GR. Application of neem gum for aqueous film coating of ciprofloxacin tablets. Int J Appl Res Nat Prod. 2013;16(3):1–5.
  2. Ogaji IJ, Nep EI, Audu-Peter JD. Advances in natural polymers as pharmaceutical excipients. Pharm Anal Acta. 2012;3:146–151.
  3. Ibrahim H, Rai PP, Bangudu AB. Pharmacognostic studies of the Stem Bark of Cissus polpunea Guill & Perr. Glimp Plant Res. 1993;1:175–180.
  4. Iwe MO, Attah MA. Functional properties of the active ingredients of Cissus Pulpunea Guill. Perr. Books Ltd. Ibadan Nig. 2nd ed. 1993;289–292.
  5. Joseph JK. Physico-chemical attributes of Wild Mango (Irvingia gabonensis) Seeds. Bioresource Technology. 1995;53:179–181.
  6. Ladipo DO, Fondoun JM, Ganga N. Domestication of the Bush Mango (Irvingia Spp). Some exploitable intraspecific variations in west and central Africa. In: Domestication and International Conference Held In Nairobi, Kenya. Non-Wood Forest Products. Food and Agriculture Organisation (E.A.O). Rome, Italy 1996;9:193–205.
  7. Agbor LON. Marketing trends and potentials for Irvingia gabonensis products in Nigeria. Proc. ICRAF-IITA Conf. Irvingia gabonensis, May 3–5, Ibadan, Nigeria, 1994.
  8. Odeku OA, Patani B. Evaluation of dika nut mucilage (Irvingia gabonensis) as a binding agent in metronidazole tablet formulation. Pharm Dev Technol. 2005;10:439–446.
  9. Isimi CY, Kunle OO, Bangudu AB. Some emulsifying and suspending properties of the mucilage extracted from kernels of Irvingia gabonensis. Boll Chim Farm. 2000;139:199–204.
  10. Odeku OA, Lamprecht A, Okunlola A. Characterization and evaluation of four natural gums as polymers in formulations of diclofenac sodium microbeads. Int J Biol Macromol. 2013;58:113–120.
  11. Odeku OA, Itiola OA. Evaluation of the effect of Khaya gum on the mechanical and release properties of paracetamol tablets. Drug Dev Ind Pharm. 2003;29(3):311–320.
  12. Association of Official Analytical Chemists (A.O.A.C) Official Methods of Analysis, Centennial Ed. 14, Washington D.C USA. 1984, ISBN 13: 9780935584240.
  13. Kaur M, Oberoi DPS, Sogi DS, Gill BS. Physicochemical, morphological and pasting properties of acid treated starches from different botanical sources. J Food Sci Technol. 2011;48(4):460–465.
  14. Lin YC, Chen X. Moisture sorption–desorption–resorption characteristics and behaviour of the epoxy system. Polym. 2005;46:11994–12003.
  15. Kosmulski M, Gustafsson MJ, Rosenholm JB. Ion specificity and viscosity of rutile dispersions. Col Polym Sci. 1999;277(6):550–556.
  16. Galindo-Rodríguez SA, Puel F, Briançon S, Allémann E, Doelker E, Fessi H. Comparative scale-up of three methods for producing ibuprofen-loaded nanoparticles. Eur J Pharm Sci. 2005;25:357–367.
  17. Lopez VO, Garcia MA, Zaritzky EN. Film forming capacity of chemically modified corn starches. Carb Polym. 2007;73:573–581.
  18. Ajala TO, AkinAjani OD, Ihuoma-Chidi C, Odeku OA. Chrysophyllum albidum mucilage as a binding agent in paracetamol tablet formulations. J Pharm Inves. 2016; 46(6):565–573.
  19. Sciarini LS, Maldonado F, Ribotta PD, Pérez GT, León AE. Chemical composition and functional properties of Gleditsia triacanthos gum. Food Hydrocol. 2009;23:306–313.
  20. Okafor IS, Chukwu A, Udeala OK. Some physical properties of Grewia gum. Nig J Polym Sci Tech. 2001;2(1):76–83.
  21. Abramovic H, Klofutar C. Water adsorption isotherms of some gellan gum samples. J Food Eng. 2006;77(3):514–520.
  22. Sothornvit R, Krochta JM. Plasticizers in edible films and coatings, in Innovations. In: J. H. Han (Ed.), Innovations in food packagings Amsterdam, The Netherlands: Elsevier. 2005:403–428.
  23. Hover R. Composition, molecular structure and physicochemical properties of tuber and root starches: a review. Carbo Polym. 2001;4:29–35.
  24. Manek RV, et al. Physical, thermal and sorption profile of starch obtained from Tacca leontopetaloides. Starch–Starke 2005;57(2):55–61.
  25. Bravo-Osuna I, Ferrero C, Jiménez-Castellanos MR. Water sorption-desorption behaviour of methyl methacrylate-starch copolymers: Effect of hydrophobic graft and drying method. Eur J Pharm Biopharm. 2005;59:537–548.
  26. Beery KE, Ladisch MR. Chemistry and properties of starch-based dessicants. Enzym Microbial Tech. 2001;28:573–581.
  27. Luangtanan-Anan M, Fell JT. Bonding mechanisms in tableting. Inter J Pharm. 1990;60:197–202.
© Wroclaw Medical University