Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2015, vol. 45, nr 1, January-June, p. 25–30

Publication type: original article

Language: English

Creative Commons BY-NC-ND 3.0 Open Access

Extraction and Characterization of Boswellia Serrata Gum as Pharmaceutical Excipient

Sumedha Pant1,A,B, Rishabha Malviya1,C,D,E, Pramod Sharma1,F

1 Department of Pharmacy, Galgotias University, Greater Noida, India

Abstract

Background. This manuscript deals with the purification and characterization of Boswellia serrata gum as a suspending agent. The Boswellia serrata gum was purchased as crude material, purified and further characterized in terms of organoleptic properties and further micromeritic studies were carried out to characterize the polymer as a pharmaceutical excipient. The suspending properties of the polymer were also evaluated. The results showed that the extracted gum possesses optimum organoleptic as well as micromeritic and suspending properties.
Objectives. To characterize Boswellia serrata gum as a natural excipient.
Material and Methods. Boswellia serrata gum, paracetamol, distilled water.
Results. The results showed that the extracted gum possesses optimum organoleptic as well as micromeritic and suspending properties.
Conclusion. It is concluded from the research work that the gum extracted from Boswellia serrata shows the presence of carbohydrates after chemical tests. All the organoleptic properties evaluated were found to be acceptable. The pH was found to be slightly acidic. Swelling Index reveals that the gum swells well in water. Total ash value was within the limits. The values of angle of repose and Carr’s Index of powdered gum powder showed that the flow property was good. IR spectra confirmed the presence of alcohol, amines, ketones, anhydrides and aromatic rings. The suspending properties of Boswellia serrata gum were found to be higher as compared to gum acacia while the flow rate of Boswellia serrata gum (1% suspension) was less than gum acacia (1% suspension). The viscosity measurement of both Boswellia serrata gum suspension and gum acacia suspension showed approximately similar results.

Key words

natural polymer, Boswellia serrata gum, drug delivery, pharmaceutical excipients, purification

References (17)

  1. Kumar S., Gupta S.K.: Natural polymers, gums and mucilages as excipients in drug delivery. Polim. Med. 2012, 42, 191–197.
  2. Malviya R., Srivastava P., Kulkarni G.T.: Applications of Mucilages in Drug Delivery – A Review. Adv. Biol. Res. 2011, 5, 01–07.
  3. Avachat A.M., Dash R.R., Shrotriya S.N.: Recent Investigations of Plant Based Natural Gums, Mucilages and Resins in Novel Drug Delivery Systems. Ind. J. Pharm. Edu. Res. 2011, 45, 86–99.
  4. Jani G.K., Shah D.P., Prajapati V.D., Jain V.C.: Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian J. Pharm. Sci. 2009, 4, 308–322.
  5. Deogade U.M., Deshmukh V.N., Sakarkar D.M.: Natural Gums and Mucilage’s in NDDS: Applications and Recent approaches. IJPRIF 2012, 4, 799–814.
  6. Maru S.G., Prakash S.B., Dharmesh S.B., Agham S.A., Aghera N.J.: Natural Polymer: Gums and Mucilage as Good Pharmaceutical Excipients. PhTechMed 2012, 2, 64–74.
  7. Shanmugam S., Manavalan R., Venkappayya D., Sundaramoorthy K., Mounnissamy V.M., Hemlatha S., Ayyappan T.: Natural Polymer and their applications. Natural Product Radiance 2005, 4, 478–481.
  8. Reddy M.R., Manjunath K.: Pharmaceutical Applications of Natural Gums, Mucilages and Pectins – A Review. Int. J. Pharm. Chem. Sci. 2013, 2, 1233–1239.
  9. Kumar T., Gupta S.K., Prajapati M.K., Tripathi D. K., Sharma V., Jain P.: Natural Excipients: A Review. Asian J. Pharm. Life Sci. 2012, 2, 97–108.
  10. Tekade B.W., Chaudhari Y.A.: Gums and Mucilages: Excipients for modified Drug Delivery System. J. Adv. Pharm. Edu. & Res. 2013, 3, 359–367.
  11. Kulkarni G.T., Gowthamarajan K., Kumar S.M.N., Suresh B.: Gums and Mucilages Therapeutic and Pharmaceutical Applications. Natural product Radiance 2002, 10–17.
  12. Krishna L.N.V., Kulkarni P.K., Dixit M., Lavanya D., Raavi P.K.: Brief Introduction of Natural Gums, Mucilages and their Applications in Novel Drug Delivery Systems – a review. IJDFR 2011, 2, 54–71.
  13. Malviya R.: Extraction Characterization and Evaluation of Selected Mucilage as Pharmaceutical Excipient. Polim. Med. 2011, 41, 39–44.
  14. Gaud R.S., Gupta G.D.: Practical Physical Pharmacy. CBS Publishers and Distributors Pvt. Ltd., Reprint 2011.
  15. Joseph L., George M.: Pharmacognostical profiling of Geranium ocellatum leaves. Int. J. Med. Arom. Plants. 2011, 1, 351– 354.
  16. Somboonpanyakul P., Wang Q., Cui W., Barbut S., Jantawat P.: Malwa nut gum. (Part I): Extraction and physicochemical characterization. Carbohydr. Polym. 2006, 64, 247–253.
  17. Malviya R., Srivastava P., Kumar U., Bhargava C.S., Sharma P.K.: Formulation and comparison of suspending properties of different natural polymers using paracetamol suspension. Int. J. Drug Dev. & Res. 2010, 2, 886–891.
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