Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2015, vol. 45, nr 1, January-June, p. 11–19

Publication type: original article

Language: English

Creative Commons BY-NC-ND 3.0 Open Access

Crosslinked Porous Starch Particles – a Promising Carrier

Tarique Ali Meer1,A,C,D,E, Kailas Moravkar1,B, Jaywant Pawar1,B, Purnima Amin1,E,F

1 Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, India

Abstract

Background. Starch is one of the most potential natural polymers used for various bio applications. Literature reports a number of modification strategies such as physical, chemical, enzymatic and genetic to enhance the positive attributes and iron out the undesired features of neat starch.
Objectives. To synthesize a crosslinked porous starch (CPS) as an efficient cargo for the delivery of calcium carbonate in an efficiently controlled manner for the treatment of hyperphosphatemia.
Material and Methods. The CPS carrier was synthesized using a natural crosslinker, malic acid. The drug delivery system was formulated, followed by the in situ loading of calcium carbonate during the preparation of the CPS. The developed system was characterized with respect to FTIR, DSC, SEM, moisture content, zeta potential, encapsulation efficiency, phosphate binding efficiency and dissolution studies.
Results. The developed formulation was observed to deliver calcium carbonate in an enterically controlled manner. The binding of calcium to phosphate was established to be pH dependent and efficient at pH 7. The moisture content of CPS was in the range of 0.2–0.8%. The zeta potential of the colloidal system was noted to be sufficiently high, indicating the stability. The encapsulation efficiency of CPS particles for calcium was found to be 88–96%
Conclusion. An efficient, cost-effective, facile and commercially-viable formulation was demonstrated to deliver calcium carbonate for the treatment of hyperphosphatemia.

Key words

calcium carbonate, crosslinked porous starch, hyperphosphatemia, delayed release, phosphate binding

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