Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2014, vol. 44, nr 3, July-September, p. 189–196

Publication type: review article

Language: Polish

Nowoczesne polimery w technologii tabletek matrycowych

Modern Polymers in Matrix Tablets Technology

Łukasz Zimmer1,A,B,C,D,E,F, Regina Kasperek1,B,C,E, Ewa Poleszak1,E,F

1 Katedra i Zakład Farmacji Stosowanej Uniwersytetu Medycznego w Lublinie, Lublin, Polska

Streszczenie

Tabletki matrycowe są najbardziej popularną metodą doustnego podawania leku z kontrolowaną szybkością uwalniania. Są otrzymywane przez umieszczenie substancji leczniczej w polimerowej matrycy. Głównym zadaniem systemu matrycowego jest przedłużenie profilu uwalniania leku w celu utrzymania jego stałego stężenia we krwi, zmniejszenie częstotliwości podawania oraz ułatwienie stosowania leku przez pacjenta. Polimerowe tabletki matrycowe wykazują duży potencjał jako doustne kontrolowane systemy dostarczania leku. Często stosowanym półsyntetycznym polimerem używanym jako matryca jest hydroksypropylometyloceluloza (HPMC). Również inne rodzaje polimerów mogą być stosowane do tego celu, m.in.: Kollidon® SR, polimery kwasu akrylowego: Eudragit® i Carbopol®. Polimery pochodzenia naturalnego, np.: karagen, chitozan, alginiany używane w przemyśle spożywczym i kosmetycznym, także stały się przedmiotem badań w farmacji i są stosowane w technologii tabletek matrycowych. Zastosowanie nowoczesnych polimerów umożliwia otrzymanie tabletek matrycowych w drukarkach 3D, co otwiera nowe możliwości rozwoju formulacji postaci leku. W niniejszej publikacji opisano polimery stosowane w technologii tabletek matrycowych oraz przykłady ich zastosowania.

Abstract

Matrix tablets are the most popular method of oral drug administration, and polymeric materials have been used broadly in matrix formulations to modify and modulate drug release rate. The main goal of the system is to extend drug release profiles to maintain a constant in vivo plasma drug concentration and a consistent pharmacological effect. Polymeric matrix tablets offer a great potential as oral controlled drug delivery systems. Cellulose derivatives, like hydroxypropyl methylcellulose (HPMC) are often used as matrix formers. However, also other types of polymers can be used for this purpose including: Kollidon® SR, acrylic acid polymers such as Eudragits® and Carbopols®. Nevertheless, polymers of natural origin like: carragens, chitosan and alginates widely used in the food and cosmetics industry are now coming to the fore of pharmaceutical research and are used in matrix tablets technology. Modern polymers allow to obtain matrix tablets by 3D printing, which enables to develop new formulation types. In this paper, the polymers used in matrix tablets technology and examples of their applications were described.

Słowa kluczowe

polimery, tabletki matrycowe, kontrolowane uwalnianie, podawanie leku, substancje pomocnicze

Key words

polymeric materials, matrix tablets, controlled release, drug delivery, excipients

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