Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2013, vol. 43, nr 4, October-December, p. 302–312

Publication type: review article

Language: Polish

Perspektywy wykorzystania polimerowych rusztowań w rekonstrukcji oraz stymulacji regeneracji pourazowych uszkodzeń mózgu

The Outlook for the Use of Polymeric Scaffolds in the Reconstruction and the Regeneration Stimulation of Traumatic Brain Injuries

Anna Lis1,B,C,D, Dariusz Szarek2,E,F, Dariusz Szarek3,E,F, Jadwiga Laska1,E,F

1 Katedra Biomateriałów, Akademia Górniczo-Hutnicza w Krakowie, Kraków, Polska

2 Katedra Neurochirurgii, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wrocław, Polska

3 Oddział Neurochirurgii, Szpital im. T. Marciniaka, Centrum Medycyny Ratunkowej we Wrocławiu, Wrocław, Polska

Streszczenie

Schorzenia neurologiczne, takie jak udary krwotoczne lub niedokrwienne mózgu czy urazy powodują przeważnie przerwanie ciągłości struktur mózgu i w związku z tym utratę wielu funkcji neurologicznych. Aktualne kliniczne strategie leczenia skutków uszkodzeń tkanki nerwowej mózgu są ograniczone. Można wprawdzie ograniczyć proces degeneracji lub łagodzić objawy, ale nie zmienia to faktu, że wiele poszkodowanych osób nigdy nie powraca do stanu sprzed zachorowania oraz wymaga długotrwałej rehabilitacji. Strategie regeneracyjne oparte na terapiach komórkowych oraz rusztowaniach polimerowych są nadzieją dla wielu pacjentów. Rusztowania polimerowe mogą wzmocnić prawdopodobieństwo sukcesu terapii komórkowych poprzez stworzenie sztucznej macierzy pozakomórkowej, która ułatwi przeżycie, proliferację, różnicowanie oraz spójność przeszczepionych i endogennych komórek. Niniejszy artykuł prezentuje wyselekcjonowane formy polimerowych rusztowań, które zostały zbadane pod kątem możliwości wspomagania procesów naprawczych w tkance nerwowej mózgu oraz ich potencjalne zastosowania kliniczne w leczeniu ubytków pourazowych oraz chorób neurodegeneracyjnych.

Abstract

Neurological disorders and injuries such as ischemic or haemorrhagic strokes or traumatic brain injuries result in the damage of cerebral parenchyma structures and in consequence, the loss of neurological functions. The current clinical strategies for the treatment of the brain nervous tissue disruptions are limited. The aforementioned methods can reduce the tissue degeneration or mitigate the subsequent symptoms, but do not alter the fact that many of the affected people are incapable of returning to the condition before the accident and they need long-lasting rehabilitation. Regenerative strategies based on the cell therapies and the use of polymeric scaffolds seem to be very promising for many patients. Polymer scaffolds may provide an opportunity to enhance the probability of cell therapy success by creating an artificial extracellular matrix which further facilitates cell survival, proliferation, differentiation, and promotes integrity of transplanted as well as endogenous cells. This paper presents selected forms of the polymeric scaffolds, which have been tested for the restoration processes within brain tissue and their potential clinical applications of scaffolds in both the treatment of posttraumatic neuronal loss and the neurodegenerative disorders.

Słowa kluczowe

polimery, ośrodkowy układ nerwowy, mózg, tkanka nerwowa, regeneracja

Key words

polymers, central nervous system, brain, nerve tissue, regeneration

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