Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2013, vol. 43, nr 4, October-December, p. 227–229

Publication type: original article

Language: English

In Vitro Determination of Aceclofenac Mouth Dissolving Tablets

Shobhit Kumar1,A,B,C,D,E, Satish Kumar Gupta1,A,F

1 Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, India

Abstract

In the present study, Mouth Dissolving Tablets (MDTs) of aceclofenac were formulated by direct compression technique. Sodium starch glycolate and crospovidone were employed as superdisintegrants in various concentrations like 2%, 3% and 4% w/w. All prepared tablets were evaluated for weight variation, hardness, drug content, friability, disintegration time, in vitro wetting time and percent drug release. MDTs containing 4% w/w concentration of crospovidone give best results and is therefore considered as the best formula. It has shown 30 s disintegration time, 25 s wetting time and 79.34% in vitro release of drug in 25 min.

Key words

aceclofenac, mouth dissolving tablets, crospovidone, sodium starch glycolate

References (13)

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