Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2012, vol. 42, nr 2, April-June, p. 97–107

Publication type: review article

Language: English

Solid dispersion in pharmaceutical technology. Part II. The methods of analysis of solid dispersions and examples of their application

Stałe rozproszenia w technologii postaci leku. Część II. Metody badania stałych rozproszeń i przykłady ich zastosowania

Bożena Karolewicz1,, Agata Górniak2,, Artur Owczarek1,, Karol Nartowski1,, Ewa Żurawska-Płaksej3,, Janusz Pluta1,

1 Department of Drug Form Technology, Wroclaw Medical University

2 Department of Inorganic Chemistry, Wroclaw Medical University

3 Department of Pharmaceutical Biochemistry, Wroclaw Medical University

Abstract

In the first part of the article solid dispersions were classified the properties and methods of their preparation were described. This section presents methods of analysis of solid dispersions i.e.: thermoanalytical methods, XRPD, FTIR, microscopic methods, dissolution studies and examples of drug forms where solid dispersions were used.

Streszczenie

W pierwszej części artykułu dokonano klasyfikacji stałych rozproszeń, opisano właściwości i metody ich otrzymywania. W tej części przedstawiono metody badań stałych rozproszeń tj. metody termoanalityczne, XRPD, FTIR, metody mikroskopowe i testy rozpuszczania oraz przykłady postaci leku otrzymanych z ich wykorzystaniem.

Key words

solid dispersions, XRPD, FTIR, thermoanalytical methods, microscopic methods, dissolution tests, drug dosage forms with incorporated solid dissolution

Słowa kluczowe

stałe rozproszenia, XRPD, FTIR, metody termoanalityczne, metody mikroskopowe, testy rozpuszczania, postacie leku z inkorporowanym stałym rozproszeniem

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