Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2010, vol. 40, nr 2, April-June, p. 47–55

Publication type: original article

Language: English

The influence of increased cross-linker chain length in thermosensitive microspheres on potential sun-protection activity

Wpływ długości łańcucha czynnika sieciującego w termowrażliwych mikrosferach na ich potencjalne działanie fotoochronne

Witold Musial1,, Witold Musial2,, Vanja Kokol1,, Bojana Voncina1,

1 University of Maribor, Department for Textile Materials and Design, Laboratory for Chemistry Dyes and Polymers, Slovenia

2 Wroclaw Medical University, Chair and Department of Pharmaceutical Technology, Poland

Abstract

The sun protection should involve substances with protecting activity against both UVB and UVA radiation. In this research the evaluation of thermosensitive microspheres as potential molecules for sunscreen formulations was approached, using modified Boots star rating system. The microspheres, thermosensitive N-isopropylacrylamide derivatives, have potential protecting activity against UV radiation. The MX and DX microspheres, with ethylene glycol dimethacrylate and diethylene glycol dimethacrylate crosslinker respectively, due to theirs thermosensitivity exhibit increase in protecting activity against UV radiation when heated to 45°C. The MX microspheres have higher increase in terms of UV absorbance, comparing to DX microspheres, when heated in the 25°C to 45°C range. Studied microspheres have high potential for application as components of sun-screens used in elevated temperatures.

Streszczenie

W ochronie przeciwsłonecznej wykorzystuje się substancje o aktywności ochronnej zarówno wobec promieniowania UVA, jak i UVB. W bieżących badaniach postanowiono przeprowadzić ocenę mikrosfer termowrażliwych, jako potencjalnych substancji do zastosowania w środkach ochrony przed promieniowaniem słonecznym, z zastosowaniem zmodyfikowanej metody Boots star rating system (BSRS). Termowrażliwe mikrosfery, pochodne N-izopropyloakrylamidu, charakteryzują się potencjalną aktywnością ochronną przeciwko promieniowaniu UV. Mikrosfery serii MX i DX, pochodne odpowiednio: dimetakrylanu glikolu etylenowego oraz dimetakrylanu glikolu dietylenowego, charakteryzują się wzrostem aktywności fotoprotekcyjnej w zakresie UV, w przebiegu ogrzewania do temperatury 45°C. Mikrosfery serii MX charakteryzują się większym przyrostem absorbancji w trakcie ogrzewa nia od 25oC do 45°C, w porównaniu z mikrosferami serii DX. Badane mikrosfery mogą znależć zastosowanie jako preparaty światłoochronne, stosowane w podwyższonych temperaturach.

Key words

thermosensitive microspheres, ethylene glycol dimethacrylate, diethylene glycol dimethacrylate, ultraviolet radiation, sun-screen

Słowa kluczowe

mikrosfery termowrażliwe, dimetakrylanu glikolu etylenowego, dimetakrylanu glikolu dietylenowego, promieniowanie ultrafioletowe, preparaty przeciwsłoneczne

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