Polymers in Medicine

Polim. Med.
Scopus CiteScore: 3.5 (CiteScore Tracker 3.6)
Index Copernicus (ICV 2023) – 121.14
MEiN – 70
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2010, vol. 40, nr 2, April-June, p. 37–45

Publication type: original article

Language: English

Evaluation of thermosensitive microspheres as potential components for sun-protectors

Ocena termowrażliwych mikrosfer jako potencjalnych składników preparatów chroniących przed światłem słonecznym

Witold Musial1,, Witold Musial2,, Vanja Kokol1,, Bojana Voncina1,

1 University of Maribor, Department for Textile Materials and Design, Laboratory for Chemistry Dyes and Polymers, Slovenia

2 Wroclaw Medical University, Chair and Department of Pharmaceutical Technology, Poland

Abstract

In this study thermosensitive polymeric microspheres obtained in former research were evaluated in vitro for their photoprotective activity. The UVA/UVB ratio was assessed at so called shelf temperature i.e. at 25 o C, and at elevated temperature of 45 o C. The evaluated polymers absorb higher levels of UV radiation, when heated from 25 o C to 45 o C. The MS1 polymer may be defined as polymer with high efficiency in the terms of gaining protection against UVA radiation, when heated. The MS2 absorbs both UVA and UVB radiation, and may be considered, as most protective, when heated to 45 o C. The equalized and less strong activity has the polymer MS3 when heated, with lipophilic radical implemented during synthesis.

Streszczenie

W niniejszym badaniu termowrażliwe mikrosfery polimerowe, otrzymane w poprzednich badaniach, oceniano w warunkach in vitro pod kątem ich aktywności fotoprotekcyjnej. Wartości współczynnika UVA/ UVB oceniano w temperaturze zbliżonej do temperatury przechowywania tj. ok. 25°C, oraz w temperaturze podwyższonej ok. 45°C. Badane polimery (MS1, MS2, MS3) wraz ze wzrostem temperatury od 25°C do 45 o C, wykazują odpowiednio wyższą absorbancję promieniowania UV. Polimer MS1 wykazuje dużą zdolność wzrostu pochłaniania promieniowania UV wraz ze wzrostem temperatury. Polimer MS2 pochłania w podobny sposób zarówno promieniowanie UVA, jak i promieniowanie UVB, i może być uważany za polimer o najwyższych właściwościach fotoochronnych sposród badanych. Polimer MS3, w którego syntezie zastosowano kopolimer lipofilowy, charakteryzuje się zrównoważonym i niższym od pozostałych wzrostem aktywności fotochronnej w czasie ogrzewania.

Key words

thermosensitive polymers, photoprotection, UV radiation, N-isopropylacrylamide

Słowa kluczowe

polimery termowrażliwe, działanie fotoochronne, promieniowanie UV, N-izopropyloakryloamid

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