Polymers in Medicine

Polim. Med.
Index Copernicus (ICV 2022) – 121.55
MEiN – 70
Average rejection rate – 39.13%
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2014, vol. 44, nr 2, April-June, p. 109–118

Publication type: review article

Language: English

Novel Prospective in Colon Specific Drug Delivery System

Vipin Bansal1,A, Rishabha Malviya2,B,C,E, Tanya Malaviya3,D, Pramod Kumar Sharma2,F

1 Research Associate, FR&D, Akums Drugs and Pharmaceuticals Ltd, Haridwar, UK, India

2 Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India

3 Department of Botany, University of Allahabad, Allahabad, Uttar Pradesh, India

Abstract

This review deals with the targeting of drugs to the lower gastrointestinal tract i.e. colon. Colonic drug delivery becomes important for localized action as well as for improved systemic availability of peptide and proteins. Drugs which have absorption window in the colonic region have been targeted using different novel technologies. pH sensitive polymers and prodrug based formulation have been used for the delivery of drugs into the colon. Different natural polymers have been used successfully for the delivery of drugs into the colon. Natural polymers are less toxic, biodegradable and easily available with a wide range of molecular weight and varying chemical compositions. One of the supporting properties associated with these polymers is that natural polymers can be used as approved pharmaceutical excipient.

Key words

targeted drug delivery, colonic delivery, natural polymer, colonic bacteria

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